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 Clomid


Klomifentsitrat (Clomiphen citras). 1 - [4 - (2-Dietilaminoetoksi) phenyl] -1, 2-diphenyl-2-Aether chloratus citrate.
Synonyms: Klostilbegit, Ardomon, Chloramiphene, Clomid, Clomifeni citras, Clomivid, Clostilbergyt, Dyneric, Fertilin, Fertomid, Genozym, Gravosan, Nefimol, Omifin, Pergolime, Prolifen, Serofen etc.
White or white with kremovatym crystalline powder, slightly soluble in water, moderately soluble in alcohol.
The drug is a mixture of cis and trans forms of these compounds, the more active cis-isomer content in the preparation is at least 50%.
Chemical structure akin hlortrianizenu (see) - drugs with estrogenic activity, and tamoxifen (antiestrogen).
Klomifentsitrat refers to a group of medicines called anti-estrogens. Drugs in this group specifically bind to estrogenozavisimymi receptors (estrogen receptors) in the hypothalamus and the ovaries. In small doses, they enhance the secretion of gonadotropins (prolactin, follicle stimulating and luteinizing hormone) and stimulate ovulation. At a low content of endogenous estrogens in the body, these drugs have a mild estrogenic effect, but at high levels of estrogen, they have an antiestrogenic effect. Reducing the level of circulating estrogens (depressing the secretion of large concentrations of gonadotropic hormones), they help to increase the secretion of gonadotropins. In large doses, these drugs can inhibit the secretion of gonadotropins. Progestogens and androgenic activity, they do not possess.
In connection with these properties klomifentsitrat in appropriate doses is used as a means of stimulating ovulation in anovulatory ovarian dysfunction and infertility associated with it, as well as dysfunctional uterine bleeding, amenorrhea disgonadotropnyh forms and other types of pathology associated with endocrine disorders of ovulation.
Applied also klomifentsitrat in breast cancer.
In connection with the stimulation of gonadotropin secretion is also used klomifentsitrat with androgen deficiency, oligospermia in men and delay of sexual and physical development of adolescent males.
Used for the diagnosis of pituitary gonadotrophic function.
Klomifentsitrat can be used in combination with gonadotropin-releasing hormone therapy. It is well absorbed when taken orally and is slowly released from the body; period polususchestvovaniya drug in the body is 5 - 7 days.
Take klomifentsitrat inside (regardless of meal times).
To stimulate ovulation prescribe oral dose of 50 mg (0, 05 g) 1 time a day (at night), beginning with a 5-day menstrual cycle, for 5 days.
Pre-determine the content of estrogen in the body. In the absence of the effect of repeated treatment, spending 3 - 5 courses, increasing the daily dose of 75 - 100 mg or increasing the duration of the course to 10 days. Coursework dose should not still be more than 500 mg.
When disseminated breast cancer (in women in menopause for at least 1 year) prescribed 100 mg 2 times a day (morning and evening) daily for a long period of time. With the progression of the disease the treatment is interrupted.
In the course of treatment Klomifentsitrat need constant supervision gynecologist should check ovarian function, perform vaginal examination to observe the phenomenon <pupil ", etc. should be made to closely monitor the overall condition of the patient.
Klomifentsitrat is a very effective inducer of ovulation, but it can cause some side effects. The most dangerous complication is ovarian hyperstimulation, which is manifested by pains in the lower abdomen, flatulence, menorrhagia, increase the size of the ovaries is accompanied by a sharp increase in estrogen in the body (an increase kariopiknoticheskogo index over 70 - 80% and estrogen excretion above 200 mg / day).
Men klomifentsitrat appoint 50 mg of 1 - 2 times a day for 3 - 4 months under the systematic control of semen. In the treatment of drug may be pain in the testicles.
Adolescents with delayed puberty and physical development appoint 50 - 100 mg per day (depending on body weight) courses in 10 days, all 3 courses at intervals of 1 - 3 months.
In applying Klomifentsitrat nausea, diarrhea, flushing, dizziness, allergic dermatitis, psychasthenia, thromboembolic complications, visual impairment.
Klomifentsitrat contraindicated in pregnancy, malignant and benign neoplasms, organic diseases of the central nervous system, liver disease, bleeding (not related to violation of ovulation), the propensity to thrombosis.
The signs of ovarian hyperstimulation and common side effects require dose reduction or discontinuation of the drug.
Should not be prescribed the drug (outpatient) to persons whose work requires quick mental and physical reactions.
Form release: pills to 0, 05 g (50 mg) for 30 pieces of lighting glass banks.
Storage: List B. In sheltered from light

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